Photo: Ishika Samant / Getty Images Sport / Getty Images
The San Francisco 49ers should win their game against the New York Giants at 1 p.m. ET on Sunday, Nov. 2, according to our computer projection model. If you're looking for additional projections on the final score, spread, and point total, we list those numbers below.
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49ers vs. Giants Game Info and TV Channel
- When: Sunday, November 2, 2025 at 1 p.m. ET
- Where: MetLife Stadium in East Rutherford, New Jersey
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on WFAN Sports Radio New York
49ers vs. Giants Odds and Betting Info
- Spread favorite: 49ers (-2.5)
- Moneyline: 49ers (-144), Giants (+121)
- Total: 48.5 points
49ers vs. Giants Prediction
- Pick ATS: 49ers (-2.5)
- Pick OU: Under (48.5)
Prediction:
49ers 24 - Giants 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Giants Betting Insights
- The 49ers have covered four times in eight games with a spread this season.
- The Giants have covered four times in eight matchups with a spread this year.
- San Francisco has covered the spread once this season (1-1 ATS) when playing as at least 2.5-point favorites.
- New York is 4-3 ATS this year when playing as at least 2.5-point underdogs.
- 49ers games have gone over the point total four out of eight times this season.
- Giants games have gone over the point total four out of eight times this season.
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